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Simon Ebbinghaus: Protein folding and aggregation kinetics probed in the living cell

July 18, 3:00 pm @ CRTD

July 18, 3:00 pm
Prof. Dr. Simon Ebbinghaus (Ruhr-Universität Bochum)
CRTD, Fetscherstrasse 105, Seminar room
Cellular protein misfolding and aggregation cause neurodegenerative disorders like Huntington, Parkinson, Alzheimer and prion diseases. The diseases may be predominantly caused by “gain-of-function” proteotoxicity, with misfolded proteins prefibrillar and fibrillar aggregates being the toxic species. Protein structure, folding and aggregation kinetics are predominantly investigated in vitro in aqueous solution with powerful biophysical techniques and methods. We study solvent-induced effects on protein aggregation with the focus of understanding the effects of the crowded cellular environment. We use a combination of fluorescence microscopy and temperature jump relaxation to spatio-temporally resolve these events in a single living cell and present new insights to the in vivo aggregation pathway of intrinsically discorded proteins.
Dr. Michael Schlierf (B CUBE)
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