Finding order in chaos: scientists determine the structure of glass-shaping protein in sponges
B CUBE hosts the 4th Scientific Advisory Board meeting
Zhang Group - Publications
Arranging Small Molecules with Sub-Nanometer Precision on DNA Origami Substrates for the Single-Molecule Investigation of Protein-Ligand Interactions
Small structures (accepted)
A Novel Synthetic, Xeno-free Biomimetic Surface for Serum-free Expansion of Human Mesenchymal Stromal Cells
Influence of the Geometry of Fluorescently Labelled DNA Constructs on Fluorescence Anisotropy Assay
Advancing DNA Steganography with Incorporation of Randomness
Screening a Chemically Defined Extracellular Matrix Mimetic Substrate Library to Identify Substrates That Enhance Substrate-Mediated Transfection
DNA-Encoded Fragment Libraries: Dynamic Assembly, Single-Molecule Detection, and High-Throughput Hit Validation
Aldrichimica Acta Vol. 52, No. 3, 2019 p63
Neuron-glia interaction through Serotonin-BDNF-NGFR axis underlies the regenerative neurogenesis after Amyloid toxicity in zebrafish brain
PLOS Biology, 2019
Multivalent electrostatic microtubule-interactions of synthetic peptides are sufficient to mimic advanced MAP-like behaviour
Mol Biol Cell 30(24), 2953-2968, 2019
Analysis and Modelling of Large and Heterogeneous Populations of DNA Using a PCR-Based Method
Blockchain of Signature Material Combining Cryptographic Hash Function and DNA Steganography
Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network
Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity
Cell Reports, 2019, 1307–1318
Engineering Hydrogels beyond a Hydrated Network.
Highly Conductive, Stretchable and Cell Adhesive Hydrogel by Nanoclay Doping
Second Generation DNA-Encoded Dynamic Combinatorial Chemical Libraries
Specificity from Non-Specific Interaction: Regulation of TNF-alpha Activity by DNA
Reversibly Assembled Electroconductive Hydrogel via a Host-Guest Interaction for 3D Cell Culture.
ACS Appl Mater Interfaces. 2019 Feb 15. doi: 10.1021/acsami.8b19482.
Peptidyl prolyl cis/trans isomerase activity on the cell surface correlates with extracellular matrix development.
Commun Biol. 2019 Feb 11;2:58. doi: 10.1038/s42003-019-0315-8.
The Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20-29)
Pharmacophore Nanoarrays on DNA Origami Substrates as a Single-Molecule Assay for Fragment-based Drug Discovery.
Angew Chem Int Ed Engl. 2018 Sep 14. doi: 10.1002/anie.201806778.
Donor-acceptor Stenhouse adduct-grafted polycarbonate surfaces: selectivity of the reaction for secondary amine on surface.
R. Soc. Open. Sci. 2018 Jul 25;5(7):180207. doi: 10.1098/rsos.180207.
3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues A?42-Induced Loss of Human Neural Stem Cell Plasticity.
Dev. Cell. 2018 Jul 2;46(1):85-101.e8. doi: 10.1016/j.devcel.2018.06.005.
Layer-by-Layer assembly of heparin and peptide-polyethylene glycol conjugates to form hybrid nanothin films of biomatrices
Non-covalently Assembled Electroconductive Hydrogel
Coacervation-Mediated Combinatorial Synthesis of Biomatrices for Stem Cell Culture and Directed Differentiation
Modelling Large, Dynamic, and Heterogeneous Populations Using DNA Libraries
From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns.
Sci Rep. 2017 Sep 12;7(1):11401. doi: 10.1038/s41598-017-11924-4.
Modeling Amyloid-beta42 Toxicity and Neurodegeneration in Adult Zebrafish Brain
Journal of Visualized Experiments, 2017
The effects of aging on Amyloid-beta42-induced neurodegeneration and regeneration in adult zebrafish brain.
Neurogenesis. 2017 May 2;4(1):e1322666.
In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide–Oligosaccharide Interaction in Immunocompetent Nude Mice.
Advanced Functional Materials, 2017 DOI: 10.1002/adfm.201605189
Lab-on-a-chip platform for high throughput drug discovery with DNA-encoded chemical libraries.
Proc. SPIE 10061, Microfluidics, BioMEMS, and Medical Microsystems XV, 1006111 (28 February 2017); doi: 10.1117/12.2253840
Augmented Reversible Photoswitching of Drug-Target Interaction through “Surface Borrowing”
Biochemical Pharmacology, 2016, 125, 84-92
Thioxylated cyclosporin A for studying protein-drug interactions.
Bioorg Med Chem Lett. 2016, 26(23), 5754-5756
IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-?42 Aggregation in Adult Zebrafish Brain.
Cell Rep. 2016 Oct 18;17(4):941-948. doi: 10.1016/j.celrep.2016.09.075.
New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells
Oncotarget, 2016, 7(42):68156-68169.
The pivotal role of reactivity in the design of novel biotinylation reagents for the chemical-proteomics-based identification of vascular accessible biomarkers
Journal of Proteomics 2016, 141, 57
Conformational Heterogeneity of Cyclosporin A in Cyclophilin 18 Binding
PLOS ONE 2016 Apr 15;11(4):e0153669
Designing an Antibody-based Chaperoning System through Pro-gramming the Binding and Release of Folding Intermediate
ACS Chemical Biology 2016 Apr 15;11(4):1090-7
Automated screening for small organic ligands using DNA-encoded chemical libraries
Nature Protocol 2016 Apr;11(4):764-80.
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body
J. Med. Chem. 2015, 58(10), 4180-93.
Amphipathic DNA origami nanoparticles can scaffold and deform lipid membrane vesicles
Angew. Chem. Int. Ed. Engl. 2015, 54(22), 6501-5
DNA-Encoded Dynamic Combinatorial Chemical Libraries
Angew. Chem. Int. Ed. Engl. 2015, 54(27), 7924-8
Efficient cargo delivery to parenchymal cells of the brain using a short cell-penetrating peptide.
PLoS one 2015, e0124073
Photopatterning of Multifunctional Hydrogels to Direct Adult Neural Precursor Cells
Advanced Healthcare Materials 2015, 4(4), 516-21.
Noncovalent hydrogel beads as microcarriers for cell culture.
Angew. Chem. Int. Ed. Engl. 2015, 54(13), 3962-6.
Self-Assembling Hydrogels Crosslinked Solely by Receptor-Ligand Interactions: Tunability, Rationalization of Physical Properties and 3D Cell Culture.
Chem. Eur. J. 2015, 21(8), 3178
Characterization of DNA-conjugated compounds using a regenerable chip.
Analytical Chemistry, 2015, 87(2):864-8
Open-access and Structured Data in Drug Discovery
Biomed Data J, Volume 1, Issue 1, p.39-41 (2015)
Encoding Method for Fast Deconvolution of DNA-encoded Chemical Library.
(German patent 102014200446.2 approved)
Light Induced Inhibition of Protein Phosphatase Calcineurin
Chin. J. Chem. 2014, 32, 1011
Chapter 16. Hit Identification and Hit Follow-up
A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery. 2014, p357-376 (Wiley)
A Repertoire of Peptide Tags for Controlled Drug Release from Injectable Non-covalent Hydrogel.
Biomacromolecules. 2014, 15(6), 2058-66.
Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins.
Developmental Cell. 2014, 28(5), 573-87
Chaperone-like effects of a scFv antibody on the folding of human muscle creatine kinase.
Protein Eng. Des. Sel. 2013, 26(8), p523-31
Minimal Peptide Motif for Non-covalent Peptide-Heparin Hydrogels
J. Am. Chem. Soc. 2013 Feb 27;135(8):2919-22.
Switchable domain partitioning and diffusion of DNA origami rods on membranes
Faraday Discussion, 2013, 161, 31
Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library.
Chemistry - A European Journal 2012 Jun 18;18(25):7729-37
Reversible photoswitching of protein function.
Mol. Biosyst. 2010 Nov;6(11):2103-9.
Discovery of TNF inhibitors from a DNA-encoded chemical library based on diels-alder cycloaddition
Chem Biol. 2009 16(10):1075-86.
Augmented photoswitching modulates immune signaling.
Nature Chem. Biol. 2009 5(10):724-6.
High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries.
Proc. Natl. Acad. Sci. 2008 105(46):17670-5.
Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library.
Angew. Chem. Int. Ed. Engl. 2007 46(25):4671-4.
Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression.
J. Biol. Chem. 2005 280(6):4842-50
Branches on the alpha-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding.
Chembiochem. 2004 5(7):1006-9
Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression.
J. Biol. Chem. 2004 279(4):2470-9
Substrate-based design of reversible Pin1 inhibitors.
Biochemistry. 2002 41(39):11868-77.