B CUBE
Center for Molecular Bioengineering

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Publication: A Repertoire of Peptide Tags for Controlled Drug Release from Injectable Non-covalent Hydrogel

Biomacromolecules, in press (2014)

A repertoire of conjugable tags for controlling the release of drugs from biomaterials is highly interesting for the development of combinatorial drug administration techniques. This paper describes such a system of 11 peptide tags derived from our previous work on a physical hydrogel system cross-linked through peptide - heparin interactions. A system for release experiments over 7 months was built, using the hydrogel matrix as a barrier between the reservoirs of tagged compounds and supernatant. This work represents a design of biomaterials with an integral system of drug delivery, where both the assembly process of the matrix and affinity capture/release of tagged compounds are based on the non-covalent interaction of heparin with one class of peptides.

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Reference:

Wieduwild R., Lin W., Boden A., Kretschmer K., Zhang Y.: A Repertoire of Peptide Tags for Controlled Drug Release from Injectable Non-covalent Hydrogel. Biomacromolecules. (publication date web: May 13, 2014)

DOI: 10.1021/bm500186a

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