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Zhang Group - Home

We are interested in developing chemical methods for biological and medical research and application. Our current major focuses are:


Spin-off:

DyNAbind

denovoMATRIX

Selected Publications:

In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide–Oligosaccharide Interaction in Immunocompetent Nude Mice. C. Tondera, R. Wieduwild, E. Röder, C. Werner, Y. Zhang*, J. Pietzsch* Advanced Functional Materials, 2017  

Augmented Reversible Photoswitching of Drug-Target Interaction through “Surface Borrowing”. F. Erdmann*, W. Lin, C. Platzer, M. Schmidt, W. Sippl, G. Fischer, Y. Zhang* Biochemical Pharmacology, 2016, p84 

IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid?-42 Aggregation in Adult Zebrafish Brain. P. Bhattarai, A.K. Thomas, M.I. Cosacak, C. Papadimitriou, V. Mashkaryan, C. Froc, S. Reinhardt, T. Kurth, A. Dahl, Y. Zhang, C. Kizil*, Cell Rep. 2016 Oct 18;17(4):941-948.

Designing an Antibody-based Chaperoning System through Programming the Binding and Release of Folding Intermediate. T. Liu, C. Sun, C. Li, J. Lee, Y. Park, Y. Zhang*, S. Li*, ACS Chemical Biology 2016 Apr 15;11(4):1090-7

DNA-encoded Dynamic Chemical Library. F. Reddavide, W. Lin, S. Lehnert, Y. Zhang*, Angew. Chem. Int. Ed. Engl. 2015, 7924

Non-covalent Matrix Beads as Microcarriers for Cell Culture. R. Wieduwild, S. Krishnan, K. Chwalek, A. Boden, D. Drechsel, C. Werner*, Y. Zhang* Angew. Chem. Int. Ed. Engl. 2015, 3962  

Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Kujawski S., Lin W., Kitte F., Börmel M., Fuchs S., Arulmozhivarman G., Vogt S., Theil D., Zhang Y., Antos C. L.* Developmental Cell. 2014, 28, p573-87.

Minimal Peptide Motif for Non-covalent Peptide-Heparin Hydrogels. Wieduwild R, Tsurkan M, Chwalek K, Murawala P, Nowak M, Freudenberg U, Neinhuis C, Werner C*, Zhang Y*. J. Am. Chem. Soc. 2013 Feb 27;135(8):2919-22.  

Augmented photoswitching modulates immune signaling. Zhang Y, Erdmann F, Fischer G Nature Chem. Biol. 2009 5(10):724-6. 

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries. Mannocci L, Zhang Y, Scheuermann J, Leimbacher M, De Bellis G, Rizzi E, Dumelin C, Melkko S, Neri D. Proc. Natl. Acad. Sci. 2008 105(46):17670.

Substrate-based design of reversible Pin1 inhibitors. Zhang Y, Füssel S, Reimer U, Schutkowski M, Fischer G. Biochemistry. 2002 41(39):11868-77.